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doi: 10.1016/j.addr.2017.04.008 19 AzegamiTYukiYKiyonoH

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By targeting both arms of the vicious cycleSirt1/Nrf2/HO-1/GPX4 for ferroptosis and TLR4/NF-B for inflammationEDV exemplifies a cycle-disrupting therapeutic strategy

Suggested Usage As a dietary supplement, take 1 Vcap 1 to 3 times daily with or without food.

NAPQI is neurotoxic : Crosses the placenta, depletes fetal brain glutathione, generates oxidative stress, and triggers cell death in neural tissue at doses below those causing maternal liver toxicity